GlaxoSmithKline is one of the world’s largest pharmaceutical companies, established in 2000 from the merger of four other healthcare businesses. Self-described as a science-led company, GSK is involved in the research, development and manufacturing of medicines and vaccines, as well as consumer goods for the industry. The company focuses on HIV, respiratory diseases, oncology and immunology. Several of GSK’s products are listed on the WHO’s List of Essential Medicines, such as amoxicillin and mercaptopurine. The company also developed the first malaria vaccine in the world. It has a secondary listing on the NYSE. In recent financial years, GlaxoSmithKline reported increases in total operating profit, which can be attributed to its decline in operating expenses. However, its group turnover could’ve been higher if its medicine and vaccine sales weren’t impacted by demand for the Covid-19 vaccine. It continues to pay a healthy dividend to investors in 2022.
GlaxoSmithKline Pharmaceuticals Ltd is one of the leading pharmaceutical companies in the India. It is a subsidiary of GlaxoSmithKline plc, UK, one of the world’s leading research-based pharmaceutical and healthcare companies. The company’s product portfolio includes prescription medicines and vaccines. Their prescription medicines range across therapeutic areas, such as anti-infectives, dermatology, gynaecology, diabetes, oncology, cardiovascular disease and respiratory diseases. They also offer a range of vaccines, for the prevention of hepatitis A, hepatitis B, invasive disease caused by H, influenza, chickenpox, diphtheria, pertussis, tetanus, rotavirus, cervical cancer and others. They have two manufacturing units in India, located at Nashik and Thane. Also, they have a clinical development centre in Bangalore.
GlaxoSmithKline Pharma Ltd was incorporated in the year 1927. During the year 1956, the primary production of vaccines begins at Worli. In the year 1960, the company started manufacturing Infant foods at milk drying plant at Aligarh. They also opened manufacturing facility for pharmaceuticals in Mumbai. In the year 1961, the company started manufacturing Vitamin A and betamethasone at new plant at Thane using imported raw materials. The company registered as a limited company in the year 1968. Also, they introduced the Animal health products.
In the year 1971, the company built the Research & development laboratory at Thane. Also, they relocated the SmithKline & French plant from Mumbai to Bangalore. In the year 1983, they commissioned the Nashik factory. SmithKline & Beecham became a public limited company under the new name of Eskayef Ltd in the year 1984 and one new Plant was set up in Mysore for manufacture of bulk drugs. In the year 1985, the company’s second basic drugs factory was inaugurated at Ankleshwar, Gujarat. In the year 1986, the company launched joint venture projects Vegepro Foods and Feeds Ltd and K G Gluco Biols. The company’s name was changed to Glindia Ltd in the year 1987. In the year 1988, the company commenced the production of bulk drug Ranitidine at Ankleshwar. Also, they started a joint venture project with Hindustan Foods Ltd for the manufacture of extruded foods at Usgao, Goa.
In the year 1989, the company commenced their Zinetac production at Nashik. The company’s name was changed from Glindia Ltd to Glaxo India Ltd. In the year 1990, the production of the bulk drug, cephalexin was commenced at Ankleshwar and the salbutamol inhalers at Nashik. Glaxo rated amongst the first five of India’s most respected companies (4th place), in a survey by Businessworld magazine. An agreement was signed with the Council of Scientific and Industrial Research (CSIR) during 1991. In the year 1992, the company sold their trade investments in Vegepro and Feeds Ltd. In the year 1993, they sold their investment in Hindustan Foods Ltd and Dempo Dairy Industries Ltd. Cetzine, a second-generation anti-histamine and research product of UCB Pharma (Belgium) was launched under a co-marketing agreement. In the same year Glaxo received recognition from the Ministry of Commerce as an export house.
In the year 1994, the company sold their Family Products Division to H J Heinz for a sum of Rs 210 crore. The Mysore plant received ISO 9002 certification and the new Iodex plant was inaugurated in Bangalore. In the year 1995, they inaugurated the government approved state-of-the-art Pharmacy Research & Development Centre (PR&D) at Thane to cater to the unmet medical needs and to exploit local commercial opportunities.
In the year 1998, the company acquired Biddle Sawyer Group of Companies, which was struggled in the year before. In the year 2000, Agrivet Farm Care (AFC) tied up with Merial, the world’s largest Animal Health Company, to market poultry vaccines. The company ranked 6th in ‘Business Today’ – Stern Stewart & Co. listing of India’s best Wealth Creator Companies and also the launched Seretide for Asthma. The merger of SmithKline Beecham Pharmaceuticals (India) Ltd into Glaxo India Limited was completed and the name of the company was changed to the present name GlaxoSmithKline Pharmaceuticals Ltd. Businessworld and the Indian Market Research Bureau (IMRB) named GlaxoSmithKline as India’s most respected Pharmaceutical Company in a survey in the year 2003. During the year, the company launched Cetzine (Cetirizine; anti-histamine), Zimig (terbinafine; anti-infective), CCM (calcium citrate maleate; nutritional), Cobadex CZS (multivitamin with trace elements).
In the year 2004, the company launched Priorix (measles, mumps, rubella vaccine). In the year 2005, the company launched oral contraceptives: Elogen (desogestrel and ethinylestradiol) and Zerogen (progesterone only pill). They entered into the diabetes therapeutic segment with the launch of Windia (rosiglitazone) and Windamet (rosiglitazone and metformin). In the year 2006, the company made an in-licensing alliance with Eisai Pharmaceuticals, Japan and launched Parit (rabeprazole; gastrointestinal therapy area). Also, GlaxoSmithKline divested their Agrivet Farm Care (AFC) animal health business. In the year 2007, the company launched Carzec (carvedilol) and Zemetril (cefprozil). In March 2007, the company opened new Medicinal Chemistry Laboratory at their R&D facility in Singapore. Also, they divested their other peripheral business of fine chemicals with consideration of Rs 240 crore on slump sale basis to Thermo Electron LLS India Private Ltd.
In the year 2008, the company increased the installed capacity of Tablets and Capsules from 6750 million nos to 6950 million nos. They increased the production capacity of Solids including Powders and Ointments from 1550 tonnes to 2225 tonnes. In January 2008, the company launched two of their new innovative Diphtheria, Tetanus and acellular Pertussis (DTP) vaccines, such as Boostrix and Infanrix. Also the company in well positioned to launch the breast cancer drug, Tykerb and the rotavirus vaccine, Rotarix during the year. Also, they rolled out three new Business Partnering initiatives during the year.
In the year 2009, the company launched new products, namely Benitec A (Olmesatan in combination with Amilodipine) in Cardiology, Dermocalm (Calamine lotion) in Dermatology, Ventorlin CFC free inhaler (Salbutamol) in Respiratory and Esblanem (Meropenem) in Antibiotic segments. Their Nashik site commenced manufacture and supply of Albendazole tablets to WHO for the Lymphatic Filriasis eradication programme.
In the year 2010, the company increased the installed capacity of Solids including Powders and Ointments from 2225 tonnes to 2600 tonnes. They launched some new products namely, Mycamine inj (Micafungin) in-licensed from Astellas and Parit D capsules (Rabeprazole in combination with Domperidone) in-licensed from Eisai. Cefspan (Cefixime – oral antibiotic) was relaunched with good success. Other branded generics launched during the year were Modvate 3 cream (Beclomethasone in combination with Clotrimazole and Neomycin) and Modvate AF cream (Beclomethasone in combination witr Clotrimazole) in Dermatology. Formulations of Atorvastatin and Rosuvastatin tablets were launchec in Cardiology under the brand names ‘Lilo’ and ‘Rosutec’ respectively. The combination of Paracetamol with Tramadol was launched under the brand name ‘Calpol T’.
In the year 2011, the company foray into branded generics market. Zobactin is ranked as the No. 2 brand (Dec MAT 2011, H.S.A) in a market which has more than 56 brands of Piperacillin+Tazobactum. In the Meropenem market, Esblanem is ranked at 6th position (Dec MAT 2011, H.S.A). After the successful launch of Tykerb in 2008, they expanded their presence further by introducing two new segments, Kidney Cancer and Hematology with launch of Votrient and Revolade.
In 2012, the company Introduces Metered Dose Inhaler with dose counter. On 30 September 2015, the company announced the completion of its transaction with Novartis Healthcare Pvt. Ltd. (Novartis India) whereby the company has acquired Novartis’ vaccines business and divested its marketed oncology portfolio to Novartis India. This follows a global transaction between GlaxoSmithKline plc, UK (GSK) and Novartis AG, Switzerland (Novartis) which was completed in March 2015 on the same basis. The acquisition of the vaccines business of Novartis provides GSK with an exciting opportunity to build an even stronger, sustainable global vaccines business. The transaction will enhance GSK’s vaccines portfolio and bring together its expertise in virology, bacterial infection and technological platforms to deliver a reliable supply of high quality vaccines.
During the quarter ended 30 September 2016, the company successfully launched Priorix-Tetra, a combined measles, mumps, rubella and varicella vaccine.
During the quarter ended 31 December 2016, the company successfully launched EnteroPlus, a probiotic food supplement. The company also restored the manufacturing of a key brand, Neosporin, an antibiotic used to treat minor wounds.
During the quarter ended 30 September 2017, the company announced its intention to dispose of its surplus land at Thane in Maharashtra to Oberoi Realty for Rs 555 crore subject to receipt of all regulatory and statutory approvals, as well as various conditions as agreed with the purchaser.
During the quarter ended 31 December 2017, the company received the money in advance towards disposal of Thane land. During the quarter ended 31 March 2018, the company successfully launched Biopatch, a hydrophilic wound dressing that is used to cover a wound caused by the use of percutaneous medical devices. Biopatch is recommended in skin sterilization protocol to reduce the incidence of CRBSI. Patients at risk of CRBSI are the ones in ICUs, those receiving chemotherapy and patients undergoing dialysis through catheters.
The Company has allotted fully paid up equity shares of Rs 10 each during the quarter ended 30th September 2018, pursuant to a bonus issue in ratio 1:1, as approved by the members through postal ballot. 8,47,03,017 Bonus shares have been issued by capitalization of profits transferred from general reserve.
During the FY2019,the Company spent Rs 291 crore as capital expenditure, mainly for the new Vemgal plant.
With an investment of over Rs 1000 crore, our upcoming manufacturing facility at Vemgal, Karnataka, will be the first greenfield pharmaceutical manufacturing site that GSK has built globally over the past ten years. It is also the first facility designed for the new GSK Production Systems (GPS), whereby it will deliver the concepts of zero accidents, zero defects and zero waste.
During FY2020,the company spent Rs 41 crore as capital expenditure, towards renovation of its corporate office into a modern workplace. The spread of Covid-19 from mid-March is having an unprecedented impact on people and economy. The Group has seen a slowdown in sales across some of its therapeutic areas during the quarter mainly from deferment of vaccination at clinics and slowdown in the non-essential portfolio. The Group has had a steady cash flow through the lockdown period and has been able to meet all its operational needs. There is no impact on capital and financial resources of the Group. The company launched the World’s first Quadrivalent Influenza Vaccine (QIV) Fluarix Tetra was launched in India in September 2020.
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